LETTER TO THE EDITOR SNPs in ultraconserved elements and familial breast cancer risk
نویسندگان
چکیده
Irene Catucci, Paolo Verderio, Sara Pizzamiglio, Siranoush Manoukian, Bernard Peissel, Monica Barile, Laura Tizzoni, Loris Bernard, Fernando Ravagnani, Laura Galastri, Marco A.Pierotti, Paolo Radice and Paolo Peterlongo IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan 20139, Italy, Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology, Unit of Medical Statistics and Biometry and Unit of Medical Genetics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy, Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan 20141, Italy, Cogentech, Consortium for Genomic Technologies, Milan 21039, Italy, Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan 20141, Italy, Immunohematology and Transfusion Medicine Service, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy, Direction, Associazione Volontari Italiani Sangue Comunale, Milan 20133, Italy and Scientific Direction, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy
منابع مشابه
SNPs in ultraconserved elements and familial breast cancer risk.
Ultraconserved elements (UCEs) are segments of >200 bp length showing absolute sequence identity between orthologous regions of human, rat and mouse genomes. The selection factors acting on these UCEs are still unknown. Recent studies have shown that UCEs function as long-range enhancers of flanking genes or are involved in splicing when overlapping with exons. The depletion of UCEs among copy ...
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Breast cancer is the most common cancer worldwide and is the second leading cause of death in women after lung cancer. Micro RNAs (miRNAs) are among endogenous factors which are involved in many types of cancers, including breast cancer. Single nucleotide polymorphism (SNP) in the miRNAs, might change their biological activities such as their effects on oncogenes and tumor suppressor genes. The...
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Background : After lung cancer, breast cancer is the second cause of mortality among women. Although the prevalence of this disease has been increased, but the rate of mortality has not been changed during last three decades, this may be due to early diagnosis at the first stage of disease . Objective : To determine risk factors of breast cancer in women. Design : It was a case- control s...
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